Omics, Epidemiology, and Ageing

We are interested in all thing omics, epidemiology, and ageing. Our group are based in the Centre for Genomic and Experimental Medicine at the University of Edinburgh.

Our primary research goal is to use computational models to understand the molecular mechanisms that underlie Alzheimer’s disease, leading to enhanced prediction, and ultimately mitigation of the disease. We have a passion for research into ageing and, in particular, examining the genetic and environmental contributions to health and neurodegeneration. 

You can find most of our publications here.

Oct 2021: Alzheimer's Society grant begins. Elena Bernabeu joins the group as a postdoc
Sep 2021: New Precision Medicine PhD student, Ola Chybowska, joins the group
July 2021: Rob Hillary submits his PhD thesis
June 2021: Dan Simpson passes his PhD viva!
Apr 2021: Alzheimer's Society grant award
Apr 2021: Riccardo joins the management team for the Biomedical AI PhD program
Apr 2021:  Dan Simpson submits his PhD thesis
Feb 2021: Anna passes her PhD viva with no corrections!
Nov 2020: Riccardo is now a Co-Investigator of the Generation Scotland study
Nov 2020: Anna submits her PhD thesis


Bayesian reassessment of the epigenetic architecture of complex traits

Daniel Trejo Banos, Daniel L McCartney, Marion Patxot, Lucas Anchieri, Thomas Battram, Colette Christiansen, Ricardo Costeira, Rosie M Walker, Stewart W Morris, Archie Campbell, {others}

Nature Communications, 2020, pp. 1--14

DNA methylation aging clocks: challenges and recommendations

Christopher G Bell, Robert Lowe, Peter D Adams, Andrea A Baccarelli, Stephan Beck, Jordana T Bell, Brock C Christensen, Vadim N Gladyshev, Bastiaan T Heijmans, Steve Horvath, {others}

Genome biology, 2019, p. 249

Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936

Robert F Hillary, Daniel L McCartney, Sarah E Harris, Anna J Stevenson, Anne Seeboth, Qian Zhang, David C Liewald, Kathryn L Evans, Craig W Ritchie, Elliot M Tucker-Drob, {others}

Nature communications, 2019, pp. 1--9

GWAS on family history of Alzheimer’s disease

Riccardo E Marioni, Sarah E Harris, Qian Zhang, Allan F McRae, Saskia P Hagenaars, W David Hill, Gail Davies, Craig W Ritchie, Catharine R Gale, John M Starr, {others}

Translational psychiatry, 2018, pp. 1--7

Epigenetic prediction of complex traits and death

Daniel L McCartney, Robert F Hillary, Anna J Stevenson, Stuart J Ritchie, Rosie M Walker, Qian Zhang, Stewart W Morris, Mairead L Bermingham, Archie Campbell, Alison D Murray, {others}

Genome biology, 2018, p. 136

View all


Funding, Datasets, and Collaborators

We are currently supported by:Alzheimer's Research UK, major project grant "Omics prediction of Alzheimer's disease", 2017 - 2020, £166,832.NIH U01  grant "Validation and Optimization of Epigenetic Clocks", 2018-2023, PI Steve Horvath UCLA, sub-award $...


The Marioni Group

0044 (0)131 651 8528

Centre for Genomic and Experimental Medicine

University of Edinburgh

Centre for Genomic and Experimental Medicine
Institute of Genetics and Molecular Medicine
Western General Hospital
University of Edinburgh