Omics, Epidemiology, and Ageing
We are interested in all thing omics, epidemiology, and ageing. Our group are based in the Centre for Genomic and Experimental Medicine at the University of Edinburgh.
Our primary research goal is to use computational models to understand the molecular mechanisms that underlie Alzheimer’s disease, leading to enhanced prediction, and ultimately mitigation of the disease. We have a passion for research into ageing and, in particular, examining the genetic and environmental contributions to health and neurodegeneration.
You can find most of our publications here.
News
Feb 2021: Anna passes her PhD viva with no corrections!
Nov 2020: Riccardo is now a Co-Investigator of the Generation Scotland study
Nov 2020: Anna submits her PhD thesis
Publications
Bayesian reassessment of the epigenetic architecture of complex traits
Daniel Trejo Banos, Daniel L McCartney, Marion Patxot, Lucas Anchieri, Thomas Battram, Colette Christiansen, Ricardo Costeira, Rosie M Walker, Stewart W Morris, Archie Campbell, {others}
Nature Communications, 2020, pp. 1--14
DNA methylation aging clocks: challenges and recommendations
Christopher G Bell, Robert Lowe, Peter D Adams, Andrea A Baccarelli, Stephan Beck, Jordana T Bell, Brock C Christensen, Vadim N Gladyshev, Bastiaan T Heijmans, Steve Horvath, {others}
Genome biology, 2019, p. 249
Robert F Hillary, Daniel L McCartney, Sarah E Harris, Anna J Stevenson, Anne Seeboth, Qian Zhang, David C Liewald, Kathryn L Evans, Craig W Ritchie, Elliot M Tucker-Drob, {others}
Nature communications, 2019, pp. 1--9
GWAS on family history of Alzheimer’s disease
Riccardo E Marioni, Sarah E Harris, Qian Zhang, Allan F McRae, Saskia P Hagenaars, W David Hill, Gail Davies, Craig W Ritchie, Catharine R Gale, John M Starr, {others}
Translational psychiatry, 2018, pp. 1--7
Epigenetic prediction of complex traits and death
Daniel L McCartney, Robert F Hillary, Anna J Stevenson, Stuart J Ritchie, Rosie M Walker, Qian Zhang, Stewart W Morris, Mairead L Bermingham, Archie Campbell, Alison D Murray, {others}
Genome biology, 2018, p. 136
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Projects
Funding, Datasets, and Collaborators
We are currently supported by:Alzheimer's Research UK, major project grant "Omics prediction of Alzheimer's disease", 2017 - 2020, £166,832.NIH U01 grant "Validation and Optimization of Epigenetic Clocks", 2018-2023, PI Steve Horvath UCLA, sub-award $...
Contact
The Marioni Group
riccardo.marioni@ed.ac.uk
0044 (0)131 651 8528
Centre for Genomic and Experimental Medicine
Centre for Genomic and Experimental Medicine
Institute of Genetics and Molecular Medicine
Western General Hospital
University of Edinburgh
EH4 2XU