MarioniGroup


Omics, Epidemiology, and Ageing




We are interested in all thing omics, epidemiology, and ageing. Our group are based in the Centre for Genomic and Experimental Medicine at the University of Edinburgh.

Our primary research goal is to use computational models to understand the molecular mechanisms that underlie Alzheimer’s disease, leading to enhanced prediction, and ultimately mitigation of the disease. We have a passion for research into ageing and, in particular, examining the genetic and environmental contributions to health and neurodegeneration. 

You can find most of our publications here.

Publications


Bayesian reassessment of the epigenetic architecture of complex traits


Daniel Trejo Banos, Daniel L McCartney, Marion Patxot, Lucas Anchieri, Thomas Battram, Colette Christiansen, Ricardo Costeira, Rosie M Walker, Stewart W Morris, Archie Campbell, {others}


Nature Communications, 2020, pp. 1--14


DNA methylation aging clocks: challenges and recommendations


Christopher G Bell, Robert Lowe, Peter D Adams, Andrea A Baccarelli, Stephan Beck, Jordana T Bell, Brock C Christensen, Vadim N Gladyshev, Bastiaan T Heijmans, Steve Horvath, {others}


Genome biology, 2019, p. 249


Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936


Robert F Hillary, Daniel L McCartney, Sarah E Harris, Anna J Stevenson, Anne Seeboth, Qian Zhang, David C Liewald, Kathryn L Evans, Craig W Ritchie, Elliot M Tucker-Drob, {others}


Nature communications, 2019, pp. 1--9


GWAS on family history of Alzheimer’s disease


Riccardo E Marioni, Sarah E Harris, Qian Zhang, Allan F McRae, Saskia P Hagenaars, W David Hill, Gail Davies, Craig W Ritchie, Catharine R Gale, John M Starr, {others}


Translational psychiatry, 2018, pp. 1--7


Epigenetic prediction of complex traits and death


Daniel L McCartney, Robert F Hillary, Anna J Stevenson, Stuart J Ritchie, Rosie M Walker, Qian Zhang, Stewart W Morris, Mairead L Bermingham, Archie Campbell, Alison D Murray, {others}


Genome biology, 2018, p. 136


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Projects


Funding, Datasets, and Collaborators


We are currently supported by:Alzheimer's Research UK, major project grant "Omics prediction of Alzheimer's disease", 2017 - 2020, £166,832.NIH U01  grant "Validation and Optimization of Epigenetic Clocks", 2018-2023, PI Steve Horvath UCLA, sub-award $...


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Other pages



Contact



The Marioni Group



riccardo​.marioni​@ed​.ac​.uk

0044 (0)131 651 8528

Centre for Genomic and Experimental Medicine


University of Edinburgh


Centre for Genomic and Experimental Medicine
Institute of Genetics and Molecular Medicine
Western General Hospital
University of Edinburgh
EH4 2XU